Francisco Hernández de Toledo, born in La Puebla de Montalbán around 1515, was a distinguished physician, naturalist, and botanist who made significant contributions to the Spanish Renaissance. His early education began at the University of Alcalá, where he studied medicine and earned his bachelor's degree in 1536. Following his graduation, he served as the physician to the Duke of Maqueda in Toledo before moving to Seville, where he married Juana Díaz and fathered two children, Juan Hernández and María of Sotomayor.
From 1556 to 1560, Hernández worked at the Hospital y Monasterio de Guadalupe in Extremadura, where he not only practiced medicine but also managed the botanical garden and participated in anatomical dissections alongside Francisco Miró. His time in Toledo was marked by frequent visits to the royal court in Madrid, where he developed a professional relationship with the renowned anatomist Andreas Vesalius.
In 1560, Hernández briefly practiced at the Hospital de la Santa Cruz in Toledo, but it was in 1567 that he became the personal physician to King Philip II of Spain. Throughout his career, he was among the first Spanish physicians to embrace the principles of Hippocrates, Galen, and Avicenna, and he became a prolific writer, producing commentaries on Galen and Hippocrates, as well as an ambitious translation of Pliny's Natural History. Hernández's legacy as a pioneering figure in medicine and natural history endures to this day.