Mary E. Brunkow

Mary E. Brunkow, born in 1961, is a distinguished American molecular biologist and immunologist renowned for her groundbreaking contributions to the field of immunology. Her pivotal research led to the co-identification of the FOXP3 gene, which is integral to understanding the scurfy mouse phenotype. This discovery has laid the groundwork for modern regulatory T cell biology, significantly advancing our comprehension of immune system regulation.

In recognition of her exceptional work, Brunkow was awarded the Nobel Prize in Physiology or Medicine in 2025, sharing this prestigious honor with fellow scientists Fred Ramsdell and Shimon Sakaguchi. Their collaborative efforts have been instrumental in elucidating the mechanisms of peripheral immune tolerance, a critical area of study in immunology.

Brunkow's research not only highlights her expertise in molecular biology but also underscores her commitment to advancing scientific knowledge that impacts human health. Her contributions continue to inspire future generations of scientists in the field.