Polycarpus II of Byzantium, a notable presbyter, served as the bishop of Byzantium from approximately one hundred forty-one until his passing in one hundred forty-four. His tenure, though recorded variably by ancient sources, is often cited as lasting three years according to the Church historian Nikiforos Kallistos.
He succeeded Bishop Felix of Byzantium, marking a significant transition in the ecclesiastical leadership of the region. During his brief time in office, Polycarpus II contributed to the early development of the Christian community in Byzantium, navigating the challenges of his era.
Following his death, Athenodorus of Byzantium took over the bishopric, continuing the legacy of leadership that Polycarpus II had established. His time as bishop, though short, was a pivotal moment in the history of the Byzantine Church.